MEGALOBLASTIC ANEMIA

  • Hypersegmented nuclei
  • Macroovalocytes
  • Erythroid hyperplasia in bone marrow
  • Giant metamyelocytes
  • Hight bilirubin and Lactate dehydrogenase
  • Presence of Howell jolly bodies
  • Anisopoikilocytosis
  • Lack of polychromasia
  • High MCV
  • Pancytopenia

Clinical Features

  • Evidence of ineffective erythropoiesis
  • Neuropathy
  • Cognitive impairment
  • Loss of position
  • Atrophic glossitis