Serum creatinine is a better indicator of overall renal function and progression to renal failure.
Serum creatinine levels are less affected than urea levels by age, dehydration, and catabolic states, e.g. fever, sepsis, and internal bleeding as compared to UREA
Creatinine levels are also less influenced by changes in diet such as low intake of protein (providing this is not prolonged).
Increasingly the measurement of serum creatinine is being used to investigate HIV associated renal disease and to monitor patients being treated
with nephrotoxic antiretroviral drugs, e.g. tenofovir.
What are normal Ranges?
Males: 60–130 mol/l 0.7 to 1.4 mg/100 ml
Females: 40–110 mol/l 0.4 to 1.2 mg/100 ml
Lower in children depending on
muscle mass.
What does results indicate?
Increase in serum creatinine levels is associated with diseases that cause renal failure:
Diseases that can cause renal failure with a reduced GFR include glomerulonephritis (inflammation of the kidney glomeruli), pyelonephritis (inflammation of the pelvis of the kidney), and renal tuberculosis.
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