Tag Archives: CHRONIC MYELOID LEUKEMIA

CHRONIC MYELOID LEUKEMIA

Arises due to Philadelphia chromosome t(22;9) The BCL- ADR oncogene

  • Marked leukocytosis with left shift (<200×10^9)
  • Normocytic normochromic anaemia
  • Increase in basophils and platelets
  • Hypercellular bone marrow (granulopoietic predominant)
  • High serum uric acid

Clinical Features

  • Hypermetabolism
  • Splenomegaly
  • Features of anaemia
  • Abnormal platelet count
  • Renal diseases
  • Rare visual disturbance, priapism

Staging

  1. Chronic phase: more than 10% blasts
  2. Accelerated phase: 15-30% blasts, 20% basophils and thrombocytopenia
  3. Blasts phase: more than 20% blasts, it is acute and respond poorly to treatment