- Marked lymphocytosis
- Smugde cells are present
- CD 19+ and weak IgM & IgD expression
- Normochromic normocytic anaemia Reduced concentration of serum immunoglobulins
- Neutropenia and red cell aplasia
- Nodullar diffuse bone marrow, high concentration of lymphocytes
- White pulp in the skin
Clinical Features
- Lymphadenopathy
- Splenomegaly (less common)
- Hepatomegaly( late stages)
- Bruising
- Immunosupression
Staging
- Lymphocytosis >5×10^9/L
- 1 + enlarged lymph
- 2 + enlarged liver and spleen
- 3 +anemia and splenomegaly
- 4 + thrombocytopenia
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