MEGALOBLASTIC ANEMIA

• Hypersegmented nuclei
• Macroovalocytes
• Erythroid hyperplasia in bone marrow
• Giant metamyelocytes
• Hight bilirubin and Lactate dehydrogenase
• Presence of Howell jolly bodies
• Anisopoikilocytosis
• Lack of polychromasia
• High MCV
• Pancytopenia

Clinical Features

• Evidence of ineffective erythropoiesis
• Neuropathy
• Cognitive impairment
• Loss of position
• Atrophic glossitis