Total protein in c.s.f. can be measured by the following methods:
Colorimetrically using a trichloroacetic acid method.
Visual comparative semiquantitative method when a colorimeter is not available
What are normal ranges for C.S.F proteins?
0.15–0.40 g/l
What Causes increase in C.S.F Proteins?
An increase in total protein and a positive
Pandy’s test occurs in all forms of meningitis, in amoebic and trypanosomiasis meningoencephalitis,
cerebral malaria, brain tumours, cerebral injury, spinal cord compression, poliomyelitis, the GuillainBarré syndrome (often the only abnormality), and polyneuritis.
Increases in c.s.f. protein also occur in diseases which cause changes in plasma proteins such as multiple myeloma.
When the total protein exceeds 2.0 g/l (200mg%), the fibrinogen level is usually increased sufficiently to cause the c.s.f. to clot. This may occur in severe pyogenic meningitis, spinal block, or following haemorrhage.
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